Used in when a speaker is changing the conversation from a humorous note to a serious one. The speaker uses "on a serious" to warn his/her companion that he/she is going to shift the gear of the conversation to a serious note.
Synonyms for on a serious note
On this page, you will find 30 slang terms related to On a serious note. Some of the top words include: fer sar, serias, cereal, geez yer, any who, and 25 more.